Lysosomal cysteine cathepsins: signaling pathways in apoptosis
Identifieur interne : 001B36 ( Main/Exploration ); précédent : 001B35; suivant : 001B37Lysosomal cysteine cathepsins: signaling pathways in apoptosis
Auteurs : Veronika Stoka [Slovénie] ; Vito Turk [Slovénie] ; Boris Turk [Slovénie]Source :
- Biological Chemistry [ 14374315 ] ; 2007.
English descriptors
- Teeft :
- Apoptosis, Biochem, Biol, Caspase, Cathepsin, Cathepsins, Cell biol, Cell death, Chem, Cirman, Cleavage, Cysteine, Cysteine cathepsins, Cytochrome, Family members, Guicciardi, Inhibitor, Intrinsic pathway, Kagedal, Lysosomal, Lysosomal cathepsin, Lysosomal cathepsins, Lysosomal membrane, Lysosomal membrane permeabilization, Lysosomal permeabilization, Lysosomal proteases, Lysosome, Mitochondrial, Mitochondrion, Pathway, Permeabilization, Protease, Receptor, Reiners, Stoka.
Abstract
Apoptosis is the major mechanism by which eukaryotic organisms eliminate potentially dangerous, superfluous and damaged cells. Initially, nuclei and mitochondria were found to be the key organelles involved in the process. However, recent data suggest that lysosomes and the endoplasmic reticulum also play important roles in the process. A number of different stimuli were found to directly or indirectly target the lysosomal membrane, thereby inducing lysosomal permeabilization and the release of cysteine cathepsins and the aspartic protease cathepsin D into the cytosol. Once in the cytosol, cathepsins can trigger cell death by different mechanisms. Here we discuss the different signaling pathways used by lysosomal proteases to trigger apoptosis and their potential role in physiological processes.
Url:
DOI: 10.1515/BC.2007.064
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000384
- to stream Istex, to step Curation: 000384
- to stream Istex, to step Checkpoint: 000A19
- to stream Main, to step Merge: 001B47
- to stream Main, to step Curation: 001B36
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lysosomal cysteine cathepsins: signaling pathways in apoptosis</title><author><name sortKey="Stoka, Veronika" sort="Stoka, Veronika" uniqKey="Stoka V" first="Veronika" last="Stoka">Veronika Stoka</name></author><author><name sortKey="Turk, Vito" sort="Turk, Vito" uniqKey="Turk V" first="Vito" last="Turk">Vito Turk</name></author><author><name sortKey="Turk, Boris" sort="Turk, Boris" uniqKey="Turk B" first="Boris" last="Turk">Boris Turk</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:ED3A6E841955D5FB1A5382706A9B2709BCA394F1</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1515/BC.2007.064</idno><idno type="url">https://api.istex.fr/ark:/67375/QT4-7NX8ZR0J-3/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000384</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000384</idno><idno type="wicri:Area/Istex/Curation">000384</idno><idno type="wicri:Area/Istex/Checkpoint">000A19</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000A19</idno><idno type="wicri:doubleKey">14374315:2007:Stoka V:lysosomal:cysteine:cathepsins</idno><idno type="wicri:Area/Main/Merge">001B47</idno><idno type="wicri:Area/Main/Curation">001B36</idno><idno type="wicri:Area/Main/Exploration">001B36</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Lysosomal cysteine cathepsins: signaling pathways in apoptosis</title><author><name sortKey="Stoka, Veronika" sort="Stoka, Veronika" uniqKey="Stoka V" first="Veronika" last="Stoka">Veronika Stoka</name><affiliation wicri:level="1"><country xml:lang="fr">Slovénie</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, J. Stefan Institute, SI-1000 Ljubljana</wicri:regionArea><wicri:noRegion>SI-1000 Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="Turk, Vito" sort="Turk, Vito" uniqKey="Turk V" first="Vito" last="Turk">Vito Turk</name><affiliation wicri:level="1"><country xml:lang="fr">Slovénie</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, J. Stefan Institute, SI-1000 Ljubljana</wicri:regionArea><wicri:noRegion>SI-1000 Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="Turk, Boris" sort="Turk, Boris" uniqKey="Turk B" first="Boris" last="Turk">Boris Turk</name><affiliation wicri:level="1"><country xml:lang="fr">Slovénie</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, J. Stefan Institute, SI-1000 Ljubljana</wicri:regionArea><wicri:noRegion>SI-1000 Ljubljana</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="abbrev">Biological Chemistry</title><idno type="eISSN">14316730</idno><idno type="ISSN">14374315</idno><imprint><publisher>Walter de Gruyter</publisher><date type="e-published">2007</date><biblScope unit="vol">388</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="555">555</biblScope><biblScope unit="page" to="560">560</biblScope><biblScope unit="ref-count">60</biblScope><biblScope unit="fig-count">2</biblScope><biblScope unit="table-count">0</biblScope></imprint><idno type="ISSN">14374315</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">14374315</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Apoptosis</term><term>Biochem</term><term>Biol</term><term>Caspase</term><term>Cathepsin</term><term>Cathepsins</term><term>Cell biol</term><term>Cell death</term><term>Chem</term><term>Cirman</term><term>Cleavage</term><term>Cysteine</term><term>Cysteine cathepsins</term><term>Cytochrome</term><term>Family members</term><term>Guicciardi</term><term>Inhibitor</term><term>Intrinsic pathway</term><term>Kagedal</term><term>Lysosomal</term><term>Lysosomal cathepsin</term><term>Lysosomal cathepsins</term><term>Lysosomal membrane</term><term>Lysosomal membrane permeabilization</term><term>Lysosomal permeabilization</term><term>Lysosomal proteases</term><term>Lysosome</term><term>Mitochondrial</term><term>Mitochondrion</term><term>Pathway</term><term>Permeabilization</term><term>Protease</term><term>Receptor</term><term>Reiners</term><term>Stoka</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Apoptosis is the major mechanism by which eukaryotic organisms eliminate potentially dangerous, superfluous and damaged cells. Initially, nuclei and mitochondria were found to be the key organelles involved in the process. However, recent data suggest that lysosomes and the endoplasmic reticulum also play important roles in the process. A number of different stimuli were found to directly or indirectly target the lysosomal membrane, thereby inducing lysosomal permeabilization and the release of cysteine cathepsins and the aspartic protease cathepsin D into the cytosol. Once in the cytosol, cathepsins can trigger cell death by different mechanisms. Here we discuss the different signaling pathways used by lysosomal proteases to trigger apoptosis and their potential role in physiological processes.</div></front></TEI><affiliations><list><country><li>Slovénie</li></country></list><tree><country name="Slovénie"><noRegion><name sortKey="Stoka, Veronika" sort="Stoka, Veronika" uniqKey="Stoka V" first="Veronika" last="Stoka">Veronika Stoka</name></noRegion><name sortKey="Turk, Boris" sort="Turk, Boris" uniqKey="Turk B" first="Boris" last="Turk">Boris Turk</name><name sortKey="Turk, Vito" sort="Turk, Vito" uniqKey="Turk V" first="Vito" last="Turk">Vito Turk</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B36 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001B36 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:ED3A6E841955D5FB1A5382706A9B2709BCA394F1
|texte= Lysosomal cysteine cathepsins: signaling pathways in apoptosis
}}
| This area was generated with Dilib version V0.6.33. |  |